Aluminium concentration was altered essential trace elements of CNS and increased susceptibility of CNS to lipid peroxidation and induces oxidative stress of neuronal damage for formation of ROS [8,9].

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Kamakshi Memorial Hospital, Pallikaranai Chennai – 600100, Tamilnadu, India Tel: 0300, 22469200 Fax: 91- 44-66300500 E-mail: [email protected] Received date: April 28, 2013; Accepted date: June 14, 2013; Published date: June 17, 2013 Citation: Thirunavukkarasu SV, Jayanthi M, Raja S, Venkataraman S (2013) Effect of Manasamitra Vatakam Against Aluminium Induced Learning and Memory Impairment of Apoptosis in Rat’s Hippocampus and Cortex. doi: 10.4172/2157-7609.1000154 Copyright: © 2013 Thirunavukkarasu SV, et al.

Visit for more related articles at Journal of Drug Metabolism & Toxicology The present study investigates neuronal cell death and neuroprotective effect of Manasamitra vatakam ( MMV ) against Aluminum (Al)-induced toxicity in rats.

Received date: September 26, 2013; Accepted date: October 05, 2013; Published date: October 08, 2013 Citation: Shi H (2013) Heavy Metal Toxicity and Therapeutics. doi: 10.4172/2157-7609.1000e120 Copyright: © 2013 Shi H.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Yokel [5] reported that potentially damaged brain in animals and humans induced by Al toxicity [6].

Aluminum-containing chemicals are widely used in medicine, food additives, and cosmetics and are added to tap water in some areas as a flocculating agent during the water purification process, it is important to study factors that might increase the absorption of aluminum across the gastrointestinal barrier [7].More interestingly, they demonstrated that , a berbo-minearal formulation, provided protection against aluminum-induced toxicity in the rats.Furthermore, MMV markedly increased synthesis and release of neurotransmitter 5-hydroxytryptamine and decreased the expression of apoptotic genes such as .This result indicates MMV could activate learning and memory function of animals due to inhibition of apoptotic genes like Bcl-2, Bcl-x L and caspas-3 .The present study reveals that Ayurvedic formulation of Manasamitra vatakam ( MMV) as potentially inhibited neuronal apoptosis and enhanced cognitive function leads to learning memory function against Al induced neuodegenerative disease.Yet, it is not clear how MMV improves the level of 5-HT and apoptotic proteins in the rats exposed to aluminum.